Table 3.

Multivariate Cox regression analysis of potential factors affecting OS, PFS, and DMFS

Variables	OS		PFS		DMFS
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (years)		0.009		0.025
<60	Ref		Ref
≥60	1.864 (1.167–2.979)		1.529 (1.054–2.219)
Sex
Male
Female
Tumor classificationa				0.017		0.014
T1–T2			Ref		Ref
T3–T4			1.497 (1.074–2.087)		1.789 (1.124–2.850)
Nodal classificationa		0.008		0.001		<0.001
N0–N1	Ref		Ref		Ref
N2–N3	1.836 (1.171–2.878)		1.774 (1.264–2.490)		2.917 (1.751–4.859)
Chemotherapy
Yes
No
Prognostic nutritional index		0.047		0.166		0.002
≥53.0	Ref		Ref		Ref
<53.0	1.602 (1.006–2.549)		1.276 (0.904–1.801)		2.134 (1.332–3.421)
Systemic immune-inflammation index		0.003		0.002		0.002
<527.20	Ref		Ref		Ref
≥527.20	1.950 (1.256–3.028)		1.706 (1.223–2.379)		2.089 (1.310–3.331)

Notes: Bolding shows P value < 0.05.

^aTNM staging system according to the American Joint Committee on Cancer (7th edition).

Abbreviations: DMFS, distant metastasis–free survival; OS, overall survival; PFS, progression–free survival; Ref, reference.