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MAPK14 links ER stress to CMA. Multiple ER stressors lead to an EIF2AK3/PERK-dependent activation and recruitment of MAP2K4/MKK4 to the lysosomes, activating a lysosomal pool of MAPK14. Lysosomal MAPK14 directly phosphorylates the CMA receptor LAMP2A at T211 and T213. This dual phosphorylation modification constitutes a key regulatory event in modulating the LAMP2A level and oligomerization on the lysosomal membrane.
