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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Int J Dev Biol. 2018;62(6-7-8):571–582. doi: 10.1387/ijdb.170341fw

Fig. 2. Switch in super-enhancer usage in different cellular states.

Fig. 2

Super-enhancers are extensive regions within the genome containing multiple TF-recruiting sequences, i.e. enhancers. (A) Super-enhancer usage changes during differentiation of keratinocytes. Recruitment of control regions, involved in homeostasis and integrin signalling, is reduced, and replaced by areas responsible for genes involved in cell-cell junctions, apoptosis and EGFR signalling. (B) Enhancer recruitment differs in various types of cells, such as HF or IFE cells. In tumours, these enhancers determine the properties of the tumour by engagement of different genes. For example, if the cancer-originating cell is of HF origin, genes that are primed open will more likely cause metastasis (C). On the contrary, IFE cells contain enhancers primed towards cell differentiation, and hence tumours are better differentiated and rarely metastasise (D).