Table 1.

Demographic and clinical characteristics of profiled patients in comparison to the parent LIBCSP population (data from the parent study have been previously published (11)) and METABRIC cohort.

		All LIBCSP cases (n=1508)		Profiled LIBCSP cases (n=606)		METABRIC (n=1980)
Title	Group	No	%	No	%	No	%
Age of diagnosis	<50 years	407	27%	158	26%	424	21%
	50+ years	1101	73%	448	74%	1556	79%
	Missing	0		0		0
Family history of breast cancer	No first degree	1166	80%	468	80%
	First degree	295	20%	114	20%
	Missing	47		24
Menopausal status	Premenopausal	472	32%	180	30%	424	21%
	Postmenopausal	1006	68%	414	70%	1556	79%
	Missing	30		12		0
Age at menarche	<12 years	391	26%	157	26%
	12+ years	1104	74%	442	74%
	Missing	13		7
Parity status	Nulliparous	198	13%	83	14%
	Parous	1310	87%	523	86%
	Missing	0		0
Lactation (among parous)	Never	841	64%	332	63%
	Ever	469	36%	191	37%
	Missing	0		0
Body Mass Index at reference	<22.3	341	23%	128	21%
	22.3-25.1	367	25%	151	25%
	25.2-29.2	391	26%	154	26%
	>29.2	392	26%	169	28%
	Missing	17		4
Stage of breast cancer	In situ	235	16%	44	7%	0	0%
	Invasive	1273	84%	562	93%	1980	100%
	Missing	0		0		0
Tumor size	<= 2 cm	466	80%	162	72%	838	42%
	2-5 cm	102	18%	56	25%	1015	51%
	5+ cm	11	2%	6	3%	127	6%
	Missing	929		382		0
ER status (by IHC)	Negative	264	27%	119	25%	439	23%
	Positive	726	73%	356	75%	1498	77%
	Missing	518		131		43
PR status (by IHC*)	Negative	355	36%	179	38%	940	47%
	Positive	635	64%	296	62%	1040	53%
	Missing	518		131		0
HER2 status (by IHC)	Negative	554	80%	422	81%	1733	88%
	Positive	135	20%	102	19%	247	12%
	Missing	819		82		0

^*for PR expression status, METABRIC data had PR_status but not PR_IHC field

^**numbers in the table do not always add up to 1508 and 606 because of missing data