Table 2. Definitions of parameters in the within-host model (parameter values in S1 Text).
| Parameter | Definition |
|---|---|
| B | Rate of production of new RBCs |
| αX | Death rate of uninfected RBCs |
| β | Rate of infection of RBCs by merozoites |
| ei | Increase in death rate due to antimalarial drug treatment, if applicable (ei = εi if being treated; otherwise, ei = 0) |
| εi | Efficacy of antimalarial drug treatment against type i |
| αY | Death rate of infected RBCs (hemolysis following parasite replication) |
| γ | Gametocyte formation rate |
| δZ | Rate of killing by innate immunity |
| δI | Rate of killing by adaptive immunity |
| ωj | Proportion of current type i antigens recognized by adaptive immunity to type j |
| R | Number of merozoites produced per infected RBC |
| φi | Fitness cost (0 ≤ φi ≤ 1) |
| αS | Death rate of merozoites |
| αG | Death rate of gametocytes |
| ζ | Innate immunity activation rate |
| αZ | Innate immunity inactivation rate |
| σ | Maximum growth rate of adaptive immunity |
| λ | Overlap in fixed (nonvariant) antigens between strains |
| θ | Merozoite density at which growth rate of adaptive immunity is σ/2 |
| Hi | Infection status indicator for type i (Hi = 1 if infected with type i; otherwise, Hi = 0) |
| ψ | Maximum (initial) decay rate of adaptive immunity due to antigenic variation |
| k | Shape parameter for decay of adaptive immunity due to antigenic variation |
| A | Shape parameter for decay of adaptive immunity due to antigenic variation |
| αI | Decay rate of adaptive immunity in absence of infection |
| Ji | Ji = 1 if Ii > baseline value; otherwise, Ji = 0 |
| Ci | Amount of exposure to variant antigens of current type i |
| μ | Overlap in variant antigens between strains |
Abbreviation: RBC, red blood cell.