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. 2018;19(6):1639–1645. doi: 10.22034/APJCP.2018.19.6.1639

Figure 1.

Figure 1

Whole Connected Component of the PPI Network of Oral Cancer Obtained from Reactome Database by Cytoscape 3.0.2 for 74 Selected Proteins. The network consists of 1144 nodes and 2867 edges. The nodes are lay out by degree and betweenness centrality values (bigger and darker circles corresponded to higher degree and betweenness centrality). The hub-bottleneck proteins in our analysis are shown in numbers 1 to 9, which include Kininogen-1(P01042), Angiotensinogen (P01019), Annexin A1(P04083), Interleukin-8 (P10145), Immunoglobulin heavy variable 3-23(P01764), C-reactive protein (P02741), Immunoglobulin heavy constant alpha 2 (P01877), Collagen alpha-1(I) chain (P02452), and Fibronectin (P02751); respectively.