Table 3.
Laboratory Measures
| Aripiprazole (N=24) | Placebo (N=18) | Statistics Treatment Effects |
|||
|---|---|---|---|---|---|
| Baseline | Endpoint | Baseline | Endpoint | ||
| Estradiol (pg/mL) | 0.9 ± 0.5 | 1.1 ± 0.6 | 1.0 ± 0.5 | 0.8 ± 0.7 | F=0.31, df=1, 36.5, p=0.58 |
| Progesterone (pg/mL) | 26.2 ± 27.7 | 31.8 ± 28.4 | 28.3 ± 35.1 | 19.6 ± 30.1 | F=0.03, df=1, 38, p=0.86 |
| Cortisol (μg/dL) | 3.4 ± 2.0 | 3.6 ± 3.3 | 2.3 ± 1.2 | 1.9 ± 1.6 | F=0.39, df=1, 17.5, p=0.39 |
| C-telopeptide (pg/ml) | 427.9 ± 254.9 | 369.6 ± 232.5 | 373.0 ± 199.1 | 383.9 ± 282.2 | F=0.15, df=1, 28.5, p=0.70 |
| N-telopeptide (mM BCE/mmol) | 34.6 ± 14.8 | 34.1 ± 15.7 | 27.5 ± 10.2 | 27.3 ± 11.3 | F=0.23, df=1, 35.6, p=0.64 |
| Thyrotropin-releasing hormone (TRH) (pg/ml) | 13.9 ± 6.1 | 13.0 ± 9.5 | 13.7 ± 3.3 | 17.0 ± 5.2 | F=2.65, df=1, 23.3, p=0.12 |
| Parathyroid hormone (pg/ml) | 30.1 ± 9.9 | 35.4 ± 13.1 | 32.9 ± 14.6 | 34.2 ± 10.6 | F=1.61, df-1, 27.3, p=0.22 |
| Homocysteine (μmol/L) | 9.5 ± 3.7 | 8.8 ± 2.9 | 8.3 ± 3.5 | 8.1 ± 2.7 | F=0, df=1, 36.2, p=0.95 |
| Vitamin D (ng/ml) | 20.9 ± 9.0 | 24.4 ± 9.9 | 19.0 ± 6.5 | 20.1 ± 7.2 | F=0.64, df=1, 34.6, p=0.43 |
| Osteocalcin (ng/ml) | 15.7 ± 9.4 | 15.0 ± 9.6 | 14.7 ± 8.0 | 16.2 ± 10 | F=0.07, df=1, 33.4, p=0.79 |
| Bone specific alkaline phosphatase (μg/L) | 17.3 ± 5.9 | 15.9 ± 6.0 | 15.8 ± 6.6 | 14.5 ± 5.1 | F=1.03, df=1, 37.6, p=0.32 |
| Alkaline phosphatase (U/L) | 79.8 ± 17.2 | 76.8 ± 20.9 | 78.2 ± 35.7 | 78.5 ± 32.6 | F=4.88, df=1, 32.9, p=0.034 |
| Total Cholesterol (mg/dL) | 182.7 ± 37.2 | 172.4 ± 34.3 | 182.4 ± 32.0 | 175.4 ± 37.8 | F=0.01, df=1, 33.7, p=0.91 |
| High Density Lipoprotein (mg/dL) | 52.7 ± 17.1 | 50.9 ±19.0 | 48.3 ±15.7 | 48.1 ±15.7 | F=0.04, df=1, 33.4, p=0.85 |
| Low Density Lipoprotein (mg/dL) | 107.9 ±34.2 | 98.4 ± 26.4 | 109.6 ± 33.5 | 103.4 ± 29.6 | F=0.01, df=1, 32.8, p=0.91 |
| Fasting Glucose (mg/dL) | 102.1 ± 47.2 | 101.5 ± 22.6 | 99.9 ± 25.2 | 97.4 ± 17.2 | F=0.06, df=1, 34.1, p=0.81 |
| Weight (kg) | 103.0 ± 23.2 | 101.2 ± 20.7 | 98.3 ± 34.0 | 96.9 ±34.1 | F=0.35, df=1,42, p=0.56 |
| Waist Circumference (in) | 45.1 ± 7.5 | 45.2 ± 7.6 | 44.4 ± 8.0 | 42.4 ± 7.8 | F=4.15, df=1, 37.3, p=0.049 |
| BMI (kg/m2) | 37.4 ± 8.5 | 36.7 ±7.5 | 35.3 ± 11.2 | 35.1 ± 11.4 | F=0.22, df=1, 39.7, p=0.64 |
This table shows baseline and endpoint values for all laboratory measuresAlkaline phosphatase decreased in the aripiprazole group relative to placeboThe placebo group had a significantly greater change in waist circumference in the placebo group compared to aripiprazole while no change was noted in the aripiprazole group.