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. 2018 Aug 15;13:4563–4573. doi: 10.2147/IJN.S168400

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© 2018 Pereira et al. This work is published and licensed by Dove Medical Press Limited

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Effectiveness of MTX-LNC on GBM treatment.

Notes: (A) Representative images of brain and bar graphs showing tumor volume (% compared to the ipsilateral hemisphere) of glioblastoma-carrying mice treated with saline solution, MTX-LNC, or MTX, on alternate days, by the oral route. Weight loss (g) (B) and leukogram (C) of glioblastoma-carrying mice treated with saline solution, MTX-LNC, and MTX. The results are expressed as mean ± SEM, n=3–5 per group. Data were analyzed by one-way ANOVA. *P<0.05 vs control; ***P<0.01 vs control; ^@P<0.05 vs MTX.

Abbreviations: MTX-LNC, methotrexate-loaded lipid-core nanocapsules; MTX, methotrexate; GBM, glioblastoma multiforme; SEM, standard error of the mean; ANOVA, analysis of variance.