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. 2018 Aug 15;13:4563–4573. doi: 10.2147/IJN.S168400

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© 2018 Pereira et al. This work is published and licensed by Dove Medical Press Limited

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Mechanisms of MTX-LNC uptake by GL261 glioma cells.

Notes: (A) Bar graphs and (B) representative images of RhoB/MTX-LNC endocytosis by GL261 in the absence (control, 37°C) or presence of blockers Cyto D (10 µmol/L), Suc (0.5 mol/L), Amil (1 mmol/L), MβC (5 µmol/L), azide (15 mmol/L), or incubation at 4°C. The results are expressed as mean ± SEM, n=4–6. Data were analyzed by one-way ANOVA, *P<0.05 vs control. White bar: 20 µm.

Abbreviations: au, arbitrary unit; DAPI, 4′,6-diamidino-2-phenylindole; MTX-LNC, methotrexate-loaded lipid-core nanocapsules; RhoB/MTX-LNC, rhodamine B-labeled MTX-LNC; SEM, standard error of the mean; ANOVA, analysis of variance.