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Schematic of the findings in this study. The PI3K-Akt signaling pathway and Ras signaling pathway were activated in the Fvb mice and promoted breast cancer progression. The pathways regulating cellular senescence and apoptosis were enriched in the up-regulated DEGs in the Fvb.B6 mice and suppressed breast cancer progression. The oncogenic pathways validated by analyzing available human breast invasive carcinoma samples in TCGA database are indicated in red.
