Table 1.
The genes involved in ECM-receptor interaction and their functions in cancer progression.
| Gene | Log2 FC | Fuction | Cancer | Reference (PUBMED ID) |
|---|---|---|---|---|
| Npnt | 3.853332471 | Promote tumor progression | Melanoma | 18271919 |
| Spp1 | 3.146711848 | Promote tumor growth | Breast cancer | 25600648 |
| Lamb3 | 2.311440893 | Supress tumor cell apoptosis | Breast cancer | 22673183 |
| Tnc | 2.278986035 | Promote tumor metastasis | Breast cancer | 21706029 |
| Itgb3 | 2.2043643 | Promote tumor invasion | Brease cancer | 21935711 |
| Col4a5 | 1.796828833 | Promote tumor progression | Lung cancer | 25992553 |
| Cd44 | 1.75555128 | Promote tumor invasion | Breast cancer | 22621373 |
| Thbs1 | 1.713801646 | Promote tumor metastasis | Breast cancer | 23614916 |
| Hmmr | 1.662370598 | Promote tumor invasion and metastasis | Breast cancer | 24367099 |
| Sdc4 | 1.398242958 | Promote tumor metastasis | Breast cancer | 22513363 |
| Itgb4 | 1.394540634 | Promote tumor metastasis | Breast cancer | 11320086 |
| Itga6 | 1.257482721 | Promote tumor invasion and tumor-initiating cell activities | Breast cancer | 27001172 |
| Itga3 | 1.245195681 | Promote tumor invasion | Oral squamous cell carcinoma | 19130304 |
| Lama4 | –1.270026569 | Promote tumor invasion and metastasis | Liver cancer | 18084776 |
| Thbs2 | –1.336701509 | Supress tumor growth | Breast cancer | 20714802 |
| Col1a2 | –1.414277191 | Promote tumor proliferation and migration | Bladder cancer | 19424577 |
| Col4a2 | –1.607119544 | Supress tumor growth | Oral squamous cell carcinoma | 19838634 |
| Itga11 | –1.692400314 | Promote tumor growth | Prostate cancer | 26990302 |
| Lamc1 | –1.876286991 | Regulate tumor progression | Uterine carcinoma | 26343160 |
| Itga5 | –1.979636346 | Supress tumor growth | Breast cancer | 20564209 |
| Hspg2 | –2.154008804 | Regulate cancer cell chemotherapy resistance | Breast cancer | 23436656 |
| Itgb7 | –3.117291092 | Promote antitumor activity | Lung cancer | 17325197 |
| Thbs3 | –3.433549457 | Promote tumor progression | Osteosarcoma | 17022822 |
| Lama2 | –3.810378201 | Supress cancer cell growth | Liver cancer | 25159915 |
| Vwf | –3.939227195 | Promote tumor progression | Melanoma | 25977583 |
| Itga7 | –4.093037687 | Supress tumor growth | Prostate | 20460506 |
| Tnxb | –6.200235271 | Supress tumor initiation | Neurofibromas | 17202312 |
| Cd36 | –7.73946806 | Regulate cancer cell chemotherapy resistance | Breast cancer | 15050739 |