Table 2.
Strain specific pathways enriched by up-regulated DEGs at the adenoma and late carcinoma stage in the two types of mice.
| KEGG(ID) | Description | p-value |
|---|---|---|
| Adenoma (Fvb mice) | ||
| mmu05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 0.0081085 |
| mmu04392 | Hippo signaling pathway – multiple species | 0.0089201 |
| mmu05231 | Choline metabolism in cancer | 0.0140725 |
| mmu05410 | Hypertrophic cardiomyopathy (HCM) | 0.0180511 |
| mmu05211 | Renal cell carcinoma | 0.0188743 |
| mmu05416 | Viral myocarditis | 0.0227298 |
| mmu05414 | Dilated cardiomyopathy (DCM) | 0.024019 |
| mmu04151 | PI3K-Akt signaling pathway | 0.0296419 |
| mmu04919 | Thyroid hormone signaling pathway | 0.031504 |
| mmu04014 | Ras signaling pathway | 0.0320875 |
| mmu04114 | Oocyte meiosis | 0.0329362 |
| mmu00564 | Glycerophospholipid metabolism | 0.0361768 |
| mmu05166 | HTLV-I infection | 0.0380264 |
| mmu00534 | Glycosaminoglycan biosynthesis – heparan sulfate / heparin | 0.0403475 |
| mmu00561 | Glycerolipid metabolism | 0.0455971 |
| mmu04072 | Phospholipase D signaling pathway | 0.0470431 |
| Late carcinoma (Fvb mice) | ||
| mmu03010 | Ribosome | 0.000136 |
| mmu03040 | Spliceosome | 0.0002356 |
| mmu05223 | Non-small cell lung cancer | 0.0022882 |
| mmu05214 | Glioma | 0.0037957 |
| mmu03018 | RNA degradation | 0.009785 |
| mmu04141 | Protein processing in endoplasmic reticulum | 0.0155598 |
| mmu04915 | Estrogen signaling pathway | 0.0253697 |
| mmu04392 | Hippo signaling pathway – multiple species | 0.0258285 |
| mmu05410 | Hypertrophic cardiomyopathy (HCM) | 0.0313479 |
| mmu05164 | Influenza A | 0.0344478 |
| mmu05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 0.0387488 |
| mmu05134 | Legionellosis | 0.0416162 |
| mmu05414 | Dilated cardiomyopathy (DCM) | 0.0421162 |
| mmu04971 | Gastric acid secretion | 0.043973 |
| mmu05145 | Toxoplasmosis | 0.0485932 |
| mmu00220 | Arginine biosynthesis | 0.0488507 |
| mmu00670 | One carbon pool by folate | 0.0488507 |
| mmu05218 | Melanoma | 0.0496314 |
| mmu04151 | PI3K-Akt signaling pathway | 0.0532724 |
| Adenoma (Fvb.B6 mice) | ||
| mmu00052 | Galactose metabolism | 0.001631 |
| mmu05161 | Hepatitis B | 0.0025484 |
| mmu00230 | Purine metabolism | 0.0049687 |
| mmu05323 | Rheumatoid arthritis | 0.0062735 |
| mmu05230 | Central carbon metabolism in cancer | 0.0088227 |
| mmu04210 | Apoptosis | 0.0088848 |
| mmu00100 | Steroid biosynthesis | 0.0192054 |
| mmu05133 | Pertussis | 0.0234864 |
| mmu05202 | Transcriptional misregulation in cancer | 0.0285217 |
| mmu04218 | Cellular senescence | 0.0312273 |
| mmu04978 | Mineral absorption | 0.0380667 |
| Late carcinoma (Fvb.B6 mice) | ||
| mmu00052 | Galactose metabolism | 0.0007166 |
| mmu05202 | Transcriptional misregulation in cancer | 0.0018766 |
| mmu04974 | Protein digestion and absorption | 0.0129149 |
| mmu04973 | Carbohydrate digestion and absorption | 0.0161787 |
| mmu00565 | Ether lipid metabolism | 0.0194157 |
| mmu04978 | Mineral absorption | 0.0194157 |
| mmu01521 | EGFR tyrosine kinase inhibitor resistance | 0.0210883 |
| mmu04550 | Signaling pathways regulating pluripotency of stem cells | 0.021165 |
| mmu04144 | Endocytosis | 0.0219855 |
| mmu05230 | Central carbon metabolism in cancer | 0.0234871 |
| mmu05323 | Rheumatoid arthritis | 0.0252586 |
| mmu05203 | Viral carcinogenesis | 0.0310027 |
| mmu04666 | Fc gamma R-mediated phagocytosis | 0.0316522 |
| mmu04931 | Insulin resistance | 0.0361468 |