Figure 3.

LINC00152 knockdown inhibits HCC tumour growth in vivo. (a) Representative images of tumour formation in nude mice injected subcutaneously with HCCLM3 cells downexpressing either LINC00152 (lower panel) (n = 5) or shRNA-NC (upper panel) (n = 5). Tumour growth curve of xenograft tumours from nude mice in the LINC00152-knockdown group and the control group. The data are shown as the mean ± s.d. (** p < 0.01). All mice were sacrificed 5 weeks after injection. (b, c) Representative images of xenograft tumours stained with haematoxylin and eosin (H&E) and with immunohistochemical stain for Ki-67. Expression of the proliferative indicator, Ki-67, was decreased in xenograft tumours from LINC00152-knockdown cells compared with control cells.