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. 2018 Jun 23;17(8):974–984. doi: 10.1080/15384101.2018.1464834

Figure 5.

Figure 5.

The function of LINC00152 depends on CCND1. (a) Knockdown LINC00152 induced a marked increase in the proportion of cells in G0/G1, and ectopic expression of CCND1 partially abrogated the LINC00152 knockdown inducing G0/G1 arrest in both Huh7 and HCCLM3 cells (** p < 0.01, *** p < 0.001). (b) Ectopic expression of LINC00152 reduced the proportion of cells in G0/G1, and CCND1 knockdown halted the decreased in G0/G1 arrest seen in Hep3B cells with overexpressubg LINC00152 (* p < 0.05, ** p < 0.01). (c, d) CCND1 overexpression reversed the effect of reduced cell proliferation capacity in LINC00152-knockdown HCC cells, while CCND1 underexpression reversed the effect of increased cell proliferation capacity caused by overexpressing LINC00152 in HCC cells (* p < 0.05, ** p < 0.01).