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. 2018 Feb 1;15(4-5):635–648. doi: 10.1080/15476286.2017.1356563

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — Schematic representation for the role of free tRNA^Leu. Under amino acid starvation condition, free tRNA^Leu interacts with EBP1 and enhances the activation of ErbB2/ErbB2 pathway. Finally, the downstream signaling mediated by RSK1/MSK2 facilitates cancer cell proliferation.