Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 2;17(8):918–926. doi: 10.1080/15384101.2018.1467679

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Informa UK Limited, trading as Taylor & Francis Group

PMC Copyright notice

Figure 2. — Mitostemness traits: New therapeutic opportunities against cancer stem cells. The bacterial origin of present-day mitochondria can drive decision-making signaling phenomena such as those governing the retention versus loss of cancer stemness. Accordingly, metabolic symbiosis-related mitonuclear communication (top panels), bacteria-related mitoproteome (middle panels), and ancient host-related mitochondrial fission/fusion dynamics (bottom panels) might introduce new molecular avenues to therapeutically target self-renewal and maintenance of the CSC phenotype. (SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; NAD⁺: nicotinamide adenine dinucleotide; α-KG: alpha-ketoglutarate; FAD: flavin adenine dinucleotide; 2-HG: 2-hydroxyglutarate; Ac: acetylation; Me: methylation; DNMT: DNA methyltransferase; HDAC: histone deacetylase; HDM: histone demethylase; Drp1: dynamin-related protein 1; Mfn: mitofusin).