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. 2017 Sep 6;15(4-5):453–460. doi: 10.1080/15476286.2017.1343227

Figure 2.

Figure 2.

Overview of orthogonal ribosome/tRNA pairs. The mutant ribosome/tRNA pair consists of the mutant ribosome with G2251C/G2253C mutations in the 23S rRNA and the tRNA with C75G mutation. The mutant ribosome specifically recognizes the mutant tRNA, and is inert to the wild-type (WT) tRNA. Similarly, the WT ribosome exclusively utilizes the WT tRNA. These coexisting orthogonal machineries express 2 distinct peptides from a single mRNA template depending on the artificially reprogrammed genetic code and the WT genetic code.