Figure 1.

Trehalose treatment increases the life span and reduces hyperactivity and anxiety-related behavior in naglu^−/- mice. Mice were weaned 21 days after birth and immediately treated with 2% trehalose in drinking water. (a) Trehalose increased median and maximum life span (> 6 weeks) of naglu^−/- mice (N = 16). (b) Trehalose did not affect mouse body weight (36 weeks of age). (c–f) Open-field analysis of trehalose-treated and untreated naglu^−/- mice compared with WT mice at 20 weeks of age (c–d) and 36 weeks of age (e–f). Data are means ± SE. *p ≤ 0.05. ns, not significant.