Table 1.
Decreased fusion of autophagosomes with endosomes-lysosomes isolated from APP-PSEN1-SREBF2 mice compared to APP-PSEN1 mice.
| homotypic fusion | N COUNT | % FUSION |
|---|---|---|
| APP-PSEN1 | 1712 | 64.7% |
| APP-PSEN1-SREBF2 | 3656 | 36.0%*** |
Table summarizes particle counting and percentages of autophagosomes fused to endosomes-lysosomes after homotypic incubation of isolated fractions. *** P<0.001 vs APP-PSEN1 values by analysis of proportions with Chi-squared (χ2) test. Counts are from 10 different fields from 3 independent experiments.