Table 2.

Decreased fusion of autophagosomes with endosomes-lysosomes isolated from SREBF2 mice compared to WT mice.

	N COUNT	% FUSION
WT homotypic fusion	1432	63.0%
SREBF2 homotypic fusion	2298	26.4% ***
Heterotypic fusion 1: (WT APs + SREBF2 EL)	1716	28.7% ***
Heterotypic fusion 2: (SREBF2 APs + WT EL)	1472	29.8% ***,*

Table summarizes particle counting and percentages of autophagosomes (APs) fused to endosomes-lysosomes (EL) after homotypic and heterotypic incubation of isolated fractions. *** P<0.001 vs WT homotypic values, * P<0.05 vs SREBF2 homotypic values by analysis of proportions with the Chi-squared (χ²) test. Counts are from 10 different fields from 3 independent experiments.