Table 3.

In vivo treatment with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) recovers the fusogenic properties of autophagic vesicles isolated from SREBF2 mice.

	N COUNT	% FUSION
WT + RM	1239	70.3%
SREBF2 + RM	888	31.9% ***
WT + HP-β-CD + RM	509	82.0%
SREBF2 + HP-β-CD + RM	476	70.3% ###

Table summarizes particle counting and percentages of autophagosomes fused to endosomes-lysosomes after homotypic incubation of isolated fractions. RM, rapamycin. *** P<0.001 vs WT values, ### P<0.001 vs SREBF2 values by analysis of proportions with the Chi-squared (χ²) test. Counts are from 10 different fields from 3 independent experiments.