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Functional studies of other modifications. (A) Site-specific sulfation in hirudin results in highly enhanced binding toward thrombin. (B) Nitration in Hsp90 induces motor neuron death through the Fas pathway. (C) LacZ-type reporter enzyme SSβG carrying mimics of glycosylation and sulfation can be used to probe brain inflammation in vivo. (D) K120 mono-ubiquitination in H2B enhances hDot1L-mediated H3K79 methylation.
