Table 2.

Univariate and multivariate analysis of factors associated with survival and recurrence.

		OS				TR
		Univariate	Multivariate			Univariate	Multivariate
Variables		P value	HR	95%CI of HR	P value	P value	HR	95%CI of HR	P value
Age, years	> 49 vs. ≤ 49	0.574				0.611
Gender	female vs. male	0.651				0.764
HBsAg	positive vs. negative	0.570				0.336
Cirrhosis	present vs. absent	0.053				0.392
GPT/ALT, U/L	> 40 vs. ≤ 40	0.032	0.254	0.089–0.725	0.010	0.082
AFP, ng/ml	> 25 vs. ≤ 25	0.391				0.793
Tumor size, cm	> 5 vs. ≤ 5	0.829				0.965
Tumor multiplicity	multiple vs. solitary	0.026	0.913	0.259–3.215	0.887	0.528
Tumor necrosis	present vs. absent	0.929				0.620
Vascular invasion	present vs. absent	0.971				0.706
Intrahepatic metastasis	yes vs. no	0.001	4.224	1.050–16.998	0.043	0.001	5.411	2.022–14.477	0.001
TNM stage	Ⅲ+Ⅳ vs. Ⅰ+Ⅱ	0.026	2.003	0.521–7.710	0.312	0.326
Tumor differentiation	Ⅲ+Ⅳ vs. Ⅰ+Ⅱ	0.217				0.084
Fibrous capsule	present vs. absent	0.042	0.834	0.320–2.178	0.712	0.078
Invading Edge LC3B+ cells	high vs. low	0.008	0.220	0.095–0.508	< 0.001	0.001	0.323	0.164–0.637	0.001
Tumor Nest LC3B+ cells	high vs. low	0.906				0.922

Abbreviations: HBsAg, hepatitis B surface antigen; GPT, glutamic-pyruvic transaminase; AFP, alpha fetoprotein; TNM, tumor-node-metastasis.