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Atg9/ATG9A trafficking in yeast and mammalian cells. (A) Architecture of the endosomal system in mammalian cells and the major putative ATG9A sorting pathways to the PAS and phagophore membranes (red arrows). For simplicity, the potential fusion of the autophagosome with an endosome, resulting in the formation of an amphisome, is not depicted. (B) Proposed organization of the yeast endosomal system and the main Atg9 transport routes to the PAS and phagophore membranes (red arrows).
