. Author manuscript; available in PMC: 2018 Aug 22.

Published in final edited form as: Nature. 2017 Nov 22;551(7681):E6–E9. doi: 10.1038/nature24634

Extended Data Table 1.

Analysis of post-treatment simulated samples based on sequences obtained before treatment by Novitsky et al.¹⁴.

		Participant Code¹⁴
Number of replicates out of 100 that pass test(s) (p < 0.05)		B	H	OU
Test 1: Divergence	Forward evolution	10	0	36
Test 1: Divergence	Reverse evolution	4	30	0
Test 2: Evolutionary rate	Forward evolution	24	0	41
Test 2: Evolutionary rate	Reverse evolution	2	29	0
Test 3: Root-to-tip regression	Forward evolution	20	9	92
Test 3: Root-to-tip regression	Reverse evolution	56	45	1
Passes at least one test; not contradicted by other tests	Forward evolution	22	9	92
	Reverse evolution	42	46	1
Passes all three tests	Forward evolution	4	0	27
Passes all three tests	Reverse evolution	1	27	0