Table 1.
Baseline characteristics of participants
| Variable | Pre N=41 |
Early Peri N=25 |
Late Peri N=26 |
Early Post N=22 |
Late Post N=24 |
P-value |
|---|---|---|---|---|---|---|
| Age, years | 34±8 | 49±3 | 50±4 | 55±4 | 61±5 | <0.001 |
| Body mass, kg | 66.5±15.0 | 69.7±10.3 | 66.8±12.4 | 71.0±12.4 | 66.7±14.1 | 0.64 |
| BMI, kg/m2 | 24.5±5.7 | 25.7±3.7 | 24.3±4.0 | 26.4±4.8 | 25.8±5.4 | 0.44 |
| Total body fat, % | 31±7 | 34±6 | 36±7 | 38±5 | 37±8 | 0.001 |
| Trunk fat, % | 28±9 | 33±6 | 34±8 | 37±7 | 36±9 | <0.001 |
| Waist circumference, cm | 79±9 | 83±10 | 82±12 | 87±13 | 85±12 | 0.07 |
| WHR | 0.79±0.06 | 0.80±0.06 | 0.81±0.06 | 0.83±0.07 | 0.83±0.06 | 0.08 |
| VO2peak, mL/kg/min | 33.4±7.3 | 28.0±4.4 | 28.0±5.7 | 26.5±3.8 | 25.4±7.1 | <0.001 |
| Seated SBP, mmHg | 108±9 | 112±10 | 115±12 | 117±14 | 120±14 | 0.001 |
| Seated DBP, mmHg | 68±7 | 72±7 | 71±8 | 73±10 | 72±10 | 0.07 |
| Resting HR, bpm | 65±11 | 62±7 | 64±10 | 63±6 | 64±8 | 0.87 |
| Total cholesterol, mg/dL | 152±29 | 168±28 | 171±31 | 188±38 | 199±33 | <0.001 |
| LDL cholesterol, mg/dL | 88±23 | 98±26 | 101±29 | 109±28 | 123±28 | <0.001 |
| HDL cholesterol, mg/dL | 48±11 | 51±13 | 51±9 | 57±20 | 57±16 | 0.08 |
| Triglycerides, mg/dLa | 68 (52–95) | 87 (66–104) | 90 (79–109) | 82 (71–106) | 95 (68–123) | 0.03 |
| Fasted insulin, μIU/mLa | 7 (4–9) | 4 (3–9) | 7 (3–11) | 9 (4–14) | 5 (3–8) | 0.10 |
| Fasted glucose, mg/dL | 84±8 | 85±8 | 83±8 | 88±11 | 86±9 | 0.18 |
| FSH, mIU/mL | 6.3±3.4 | 22.0±30.0 | 64.1±35.5 | 73.1±26.3 | 82.7±33.2 | <0.001 |
| Estradiol, pg/mLa,b | 76 (39–92) | 70 (36–141) | 34 (10–102) | 11 (10–15) | 10 (10–15) | <0.001 |
| Progesterone, ng/mLa | 0.5 (0.2–0.8) | 0.5 (0.2–0.9) | 0.3 (0.3–0.5) | 0.3 (0.1–0.4) | 0.2 (0.1–0.4) | 0.001 |
| Estrone, pg/mLa | 59 (37–70) | 60 (34–92) | 43 (29–70) | 28 (23–35) | 26 (23–37) | <0.001 |
| Testosterone, ng/dLa,c | 30 (18–43) | 22 (17–36) | 20 (17–25) | 19 (17–23) | 17 (17–35) | 0.002 |
Data are mean±standard deviation unless otherwise stated.
a
Data are median (interquartile range)
b
Sensitivity = 10 pg/mL
c
Sensitivity = 17 ng/dL
Pre, premenopausal; Peri, perimenopausal; Post, postmenopausal; BMI, body mass index; WHR, waist hip ratio; VO2 peak, peak aerobic power; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FSH, follicle stimulating hormone