Table 1.

Characteristics of studies included in the meta-analysis

Author	Year	Region	Follow-up (month)	Age (year)	No. (M/F)	Sample size	Outcome	Cut-off value	NOS score
Porrata et al. [28]	2010	USA	59.1 (13.9–107.8)	64 (20–92)	146/109	255	OS, PFS	3.5	8
Ho et al. [11]	2015	China	53.28	61.0 (16–88)	80/68	148	OS, PFS	2.11	7
Keam et al. [23]	2015	Korea	59.0 (2.5–118.5)	61 (16–87)	226/221	447	OS, PFS	3	8
Melchardt et al. [9]	2015	Austria	53	65.3 (20–92)	270/245	515	OS	5.54	8
Ming et al. [29]	2015	China	NR	55 (20–85)	24/27	51	OS	2.32	6
Hong et al. [22]	2016	Korea	48.9 (46.5–51.3)	56 (16–86)	177/136	313	PFS	2.42	8
Ni et al. [27]	2016	China	NR	54 (14–75)	36/23	59	OS, PFS	2.915	6
Periša et al. [25]	2016	Croatia	27 (1–105)	63 (22–87)	51/66	117	OS, EFS	2.63	6
Wang et al. [26]	2016	China	29 (2–122)	NR	90/66	156	OS, PFS	3.0	6
Park et al. [24]	2016	Korea	NR	60 (32–81)	53/46	99	OS, PFS	3.5	6
Wang et al. [8]	2017	China	NR	54 (18–86)	202/153	355	OS, PFS	2.81	7

NR not reported, OS overall survival, PFS progression free survival, EFS event free survival, NOS Newcastle–Ottawa Quality Assessment Scale