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. 2018 Aug 22;11:105. doi: 10.1186/s13045-018-0652-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Chronology of specimen collections in the surveilled and non-surveilled relapsed B-ALL cases. Each horizontal line represents one patient with B-ALL relapse. The mean time interval between the most recent follow-up sample and overt relapse (marked) in the non-surveilled cases is significantly longer compared to that between conversion to positive MRD (CPMRD) and overt relapse (marked) in surveilled cases (20 months vs 4.7 months, p < 0.0001). See Fig. 6 for treatment information