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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: J Comp Neurol. 2018 Mar 9;527(3):668–678. doi: 10.1002/cne.24414

Figure 3. Schematic of our model of ocular dominance plasticity regulation by NRG1/ErbB4 signaling in PV neurons.

Figure 3

a, Down-regulation of NRG signaling following monocular deprivation (MD) reduces excitatory inputs onto PV neurons and subsequent inhibition onto excitatory neurons. The decrease of cortical inhibition is the necessary first step in ocular dominance plasticity (ODP) initiation. b, Elevated NRG in the cortex enhances excitatory inputs to PV neurons during MD, which occludes the MD-induced reduction of cortical inhibition and suppresses ODP during the normal critical period. While NRG1-ErbB4 signaling is predominant in juvenile critical period plasticity, other NRGs (particularly NRG3) signaling may also be implicated in cortical plasticity in adulthood. The schematic is modified from Sun et al. (2016) with permission from the Cell Press.