Figure 3.

Additional clinical information rated “very important” for interpreting the report, by specialty and finding. Findings include a pathogenic RYR1 variant associated with risk for malignant hyperthermia (“ACMG list”), a pathogenic PALB2 variant associated with risk for breast cancer risk (“Has ClinGen summary”), a pathogenic CHEK2 variant associated with risk for cancer (“No ClinGen summary”), a BRCA1 variant of uncertain significance in a patient with a family history of ovarian cancer (“VUS with family history”), and carrier status for three autosomal recessive conditions. P values summarize tests for non-equivalence comparing genetic specialists and non-genetic specialists (“specialty”) and comparing findings (“finding”), and include a test for interaction between specialty and finding (“interaction”).