Table 1.
LncRNAs deregulated in cancer through targeting the signals of metabolism
| LncRNA | Location | Target | Up/down | Disease |
|---|---|---|---|---|
| HIF1 and MYC | ||||
| H19 | Chr 11p15.5 | HIF1A | Up | HCC [105] |
| SNHG12 | / | C-MYC | Up | Breast cancer [113] |
| SARCC | / | AR | Down | RCC [115] |
| PCGEM1 | Chr 2q32 | C-MYC | Up | Prostatic cancer [111] |
| P53 | ||||
| HULC | Chr 6p24.3 | P53 | Up | NPC [123] |
| HOTAIR | Chr 12 | P53 | Up | Breast cancer [124] |
| PRAL | Chr 17p13.1 | P53 | Down | Lung cancer [125] |
| PI3K/AKT/MTOR | ||||
| RP11-708H21.4 | Chr 17q21 | MTOR | Down | CRC [138] |
| UCA1 | Chr 19 | MTOR/STAT3 | Up | CRC [63, 122] |
| linc00462 | / | PI3/AKT | Down | HCC [139] |
| MALAT1 | Chr 11q13 | PI3/AKT | Down | Cholangiocarcinoma [177] |
| CASC2 | Chr 10q26 | PTEN | Down | CESC [7] |
| HULC | Chr 6p24.3 | PI3/AKT | Up | Myeloid leukemia [135] |
| ANRIL | Chr 9q21 | AKT | Up | NPC, glioma, CESC [33, 40] |
| AMP-activated protein kinase | ||||
| LINC00473 | Chr 6q27 | LKB1 | Up | Lung cancer [143] |
| NBR2 | Chr 17q21 | AMPK | Down | Breast cancer [34, 42] |
Chr chromosome, HCC hepatocellular carcinoma, NPC nasopharyngeal carcinoma, RCC renal cell carcinoma, CESC cervical cancer