Table 2.

LncRNAs and miRNAs involved in regulating tumor metabolism

Gene	Target	Signaling	Potential functions and indication	Ref.
lncRNA and glucose metabolism
ANRIL	GLUT1 and LDHA	PI3/AKT/mTOR	Increase glucose uptake, prognosis	[33, 40]
NBR2	GLUT1	LKB1/AMPK	Decrease glucose uptake, increases autophagy, prognosis	[34]
CRNDE	GLUT4	PI3/AKT/mTOR	Increases glucose uptake	[30, 136]
GCASPC	miR-17-3P	HIF1/MYC	Decrease pyruvate carboxylase, prognosis	[48]
NRCP	STAT1	Not mentioned	Increase glycolysis, prognosis	[49]
PVT1	HK2	miR-497/HK2 axis	Increase glucose metabolism, prognosis	[60]
H19	let-7	HIF1/MYC	Increase insulin sensitivity, enhance glucose tolerance, prognosis	[62]
MALAT1		HIF1/MYC	Increase glycolysis	[146]
microRNA and glucose metabolism
miR-195-5p	GLUT3	LKB1/AMPK	Decrease glucose uptake	[148]
miR-210	GPD1L	HIF1/MYC	Decrease glycolysis, prognosis	[149, 150]
miR-223	c-MYC	HIF1/MYC	Increase glucose uptake, prognosis	[151]
miR-143	HK2	PI3K/AKT/mTOR	Decrease glucose metabolism	[147]
miR-21	PTEN	PI3K/AKT/mTOR	Increase glucose metabolism, prognosis	[152]
miR-326	PKM2	LKB1/AMPK	Decrease glycolysis	[153]
miR-451	CAB39	LKB1/AMPK	Increase glucose metabolism, prognosis	[156]
miR-29	MCT1	P53, PI3K/AKT/mTOR	Caused insulin resistance, prognosis	[154, 155]
LncRNA and lipid metabolism
LncHR1	SREBP-1c and FAS	PI3K/AKT/mTOR	Decrease lipid metabolism	[69]
LNMICC	miR-190	miR-190/LNMICC/FABP5 axis	Increase fatty acid metabolism, prognosis	[71]
SRA	Not mentioned	AKT/FOXO1 axis	Decrease adipogenesis and glucose uptake	[77]
HULC	miR-9	miR-9/PPARγ/ACSL1 axis	Increase the deregulation of lipid metabolism	[76]
miRNA and lipid metabolism
miR-122	CyclinB1	P53	Increase cholesterol synthesis and lipogenesis	[157]
lncRNA and glutamine metabolism
TUG1	miR-145	Sirt3/GDH axis	Increase glutamine metabolism, prognosis	[81]
UCA1	miR-16	PI3/AKT/mTOR	Increase glutamine metabolism	[160]
miRNA and glutamine metabolism
miR-23b	c-MYC	HIF1/MYC	Increase the biosynthesis of proline from glutamine	[161]