Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 21;9:3339. doi: 10.1038/s41467-018-05847-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — SOM and PV cells favor subthreshold cortical activity summation. a In the DMS and DLS, cortically evoked subthreshold EPSPs or trains of EPSPs were recorded in SPNs in control or with opto-inhibition of SOM or PV cells. b, c Representative EPSPs recorded in DMS (b) and DLS (c) in control conditions (black) or with opto-inhibition of SOM cells (purple) or PV cells (green). Individual experiments (2 measurements for each neuron) and normalized (mean ± SEM) decay time of cortically evoked EPSPs in SPNs in control condition compared to opto-inhibition of SOM and PV cells. There is a significant decrease of EPSP decay time with opto-inhibition of SOM-DMS cells (p = 0.001, n = 20, paired-test) and PV-DLS cells (p = 0.001, n = 19). d, e Top: Representatives 50 Hz trains of EPSPs recorded in SPNs in control or with selective opto-inhibition of interneurons. Bottom: Temporal summations of EPSPs in SPNs after 50 Hz cortical electrical stimulation in control conditions (black) or with opto-inhibition of SOM (purple) or PV (green) cells. d In DMS, opto-inhibition of SOM cells induces a significant decrease in summation of EPSPs (p < 0.0001, n = 24, two-way ANOVA), whereas PV cell opto-inhibition has no effect (p = 0.1338, n = 14). e In DLS, PV cell opto-inhibition induces a significant decrease in summation of EPSPs (p < 0.0001, n = 25) and SOM cell opto-inhibition has no effect (p = 0.1536, n = 17). f, g Summary of the effects of interneuron silencing on temporal summation: ratio of the third EPSP compared to the first one for the different frequencies. f In DMS, SOM cell opto-inhibition strongly affects the summation of EPSPs in the trains for most activation frequencies (10, 20, 50 and 100 Hz), whereas there is no effect of PV cell opto-inhibition. g On the contrary, in DLS, PV cells strongly affect the summation of EPSPs in the trains for 10, 20, 50 and 100 Hz while silencing of SOM cells had no effect, except for 10 Hz activation. h, i Correlation of the normalized amplitude (EPSP3/EPSP1) and the amplitude of the first EPSP of the 50 Hz train, in DMS and DLS and for SOM and PV silencing. For all the conditions, there is a significant correlation, which is similar in control conditions or after interneuron silencing; *p < 0.05, **p < 0.01, ***p < 0.001