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. 2018 Aug 21;8:12512. doi: 10.1038/s41598-018-30972-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mapping of clinical obtained mutations within the mexZ gene in P. aeruginosa. Here, mexZ mutations were mapped to one of the three functional mexZ domains; the DNA binding domain (α-helix 1 to α-helix 3), where α-helix 3 is the DNA recognition helix, and a C-terminal domain (α-helix 4 to α-helix 9)¹⁹. For each domain, the number of mexZ mutations consisting of a SNP or INDEL is noted with the accompanying MIC determination for the known MexXY-OprM substrates tobramycin, ciprofloxacin, and gentamicin. The clinical break-off points are presented according to EUCAST guidelines²¹.