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. 2018 Aug 21;9:3165. doi: 10.1038/s41467-018-05613-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — P053 is a selective inhibitor of CerS1. a Structure of G024 [1] and P053 [2]. b Activity of CerS isoforms as a function of P053 concentration (n = 3 for each concentration, mean ± SEM). c, d CerS1 activity as a function of c dihydrosphingosine or d C18:0-CoA concentration. Calculated V_max and K_half values are below the graphs. Graphs show mean ± SEM (n = 3 for each concentration), and the non-competitive inhibition was confirmed in three independent experiments for each substrate