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. 2018 Aug 21;8:12524. doi: 10.1038/s41598-018-30831-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of two heterogeneous networks, each containing different node as well as edge types (or colors). In a given network, different node shapes represent different node types, and different line styles represent different edge types. If we do not consider the ovals with red edges (the bottom portion of the network), then we have a heterogeneous network with different node types, and thus implicitly different edge types. If we only consider the ovals with blue or red edges, then we have a heterogeneous network with different edge types but a single node type (also called multimodal networks with two edge modes). The goal of HetNA as we define it is to find a node mapping between heterogeneous networks that contain different node types, different edge types, or both.