Figure 7.

Effect of HSBP1 deletion on T cell stimulated cytokine production. TNF production (A, p = 0.009) and IL-2 production (B, p = 0.002) were decreased in splenic CD4⁺ T cells of HSPB1^−/− mice stimulated ex vivo. In contrast, IFN-γ production was elevated in CD4⁺ T cells of HSPB1^−/− mice (C, p = 0.009). TNF production (D, p = 0.004) and IL-2 production (E, p = 0.002) were also decreased in splenic CD8⁺ T cells of HSPB1^−/− mice stimulated ex vivo while IFN-γ production was unchanged (F, p = 0.13). N = 10/group, all panels).