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. Author manuscript; available in PMC: 2019 Aug 16.
Published in final edited form as: Mol Cell. 2018 Aug 16;71(4):567–580.e4. doi: 10.1016/j.molcel.2018.06.039

Figure 6. Assessing the phenotypic differences between mct1Δ and mpc1Δ cells.

Figure 6

A. Proteomics experimental overview. B. Heat map and dendrogram plot demonstrating that all biological replicates cluster as expected. C,D. Volcano plots highlighting significantly (p≤0.01) up-(fold change ≥ 1.25) and down-(fold change ≤ 0.75) regulated proteins comparing WT and mct1Δ (C) and WT and mpc1Δ (D). Proteins involved in oxidative phosphorylation are emphasized in red. E. Heat map showing the fold change (log2) of the indicated proteins involved in acetyl-CoA generation.