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. 2018 Aug 21;8:12506. doi: 10.1038/s41598-018-30942-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-125b expression is downregulated in pilocytic astrocytoma, and other circumscribed gliomas compared to diffuse astrocytoma. In situ hybridization studies using probes targetting miR-125b demonstrated variable levels in low grade gliomas and glioneuronal tumors, but levels were highest in diffuse astrocytoma (DA) and lowest in pilocytic astrocytoma (PA) (p = 0.01) (Wilcoxon Rank Sum Test). Strength of ISH hybridization was scored using a 4 tiered scale semiquantitative scale, ranging from 3 (strong, similar to brain), 2 (moderate), 1 (weak), 0 (negative) (y-axis). Each dot represents an individual tumor, and BRAF mutated tumors are in red color (AG = angiocentric glioma, DNET = dysembryoplastic neuroepithelial tumor, GG = ganglioglioma, LGA = low grade astrocytoma, LGGT = low grade glioneuronal tumor, PXA = pleomorphic xanthoastrocytoma, SEGA = subependymal giant cell astrocytoma) (A). There was a non-significant trend for high miR-125b expression in tumors lacking BRAF alterations (BRAF duplications or BRAF p.V600E) as demonstrated by the two tailed Fisher exact test and contingency table (B).