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. 2018 Aug 21;8:12506. doi: 10.1038/s41598-018-30942-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of miR-125b decreases cell growth. (A) qRT-PCR of miR-125b-5p expression in pediatric cell lines. (B) Overexpression of miR-125b in Res186, Res259 and BT66 (BRAF fusion+) cells. All data were normalized with miR-control infected cells. (**p < 0.01 compare to miR-control). (C) Cell growth curve of Res186, Res259 and BT66 cells infected with miR-control and miR-125b. (*p < 0.05 and **p < 0.01 compare to miR-control). (D) Quantification of BrdU incorporation is at left and BT66 analyzed data of flow cytometer is at right (*p < 0.05 compare to miR-control). Results represent the average of at least three biological replicates and data were analyzed with a two-tailed Student’s t-test.