Table 2.
Baseline body composition and changes
| Variable (SD) | Overall (SD) | No Wasting | P valuea | Fat‐Only Wasting | P valuea | Muscle and Fat Wasting | P valuea | P value among cachexia phenotypes |
|---|---|---|---|---|---|---|---|---|
| Initial BMI (kg/m2) | 28.8 (7.3) | 26.3 (4.8) | 28.7 (12.4) | 29.5 (6.1) | 0.48 | |||
| BMI change (kg/m 2 ) | −2.9 (5.9) | 2.2 (2.7) | 0.028 | −5.5 (11.2) | 0.129 | −3.7 (3.5) | <0.001 | 0.005 |
| BMI % change | −8.3 (15.0) | 8.3 (9.4) | 0.021 | −12.5 (19.5) | 0.058 | −12.1 (11.7) | <0.001 | <0.001 |
| Initial SKMI (cm 2 /m 2 ) | 46.9 (9.5) | 44.4 (8.3) | 40.8 (7.1) | 49.2 (9.6) | 0.036 | |||
| SKM change (kg) | −3.5 (5.9) | 3.7 (5.4) | 0.056 | 0.7 (1.4) | 0.144 | −6.8 (3.9) | <0.001 | <0.001 |
| SKMI % change | −7.2 (13.3) | 10.1 (14.6) | 0.056 | 2.2 (3.5) | 0.911 | −14.8 (6.5) | <0.001 | <0.001 |
| Initial IMATI (cm2/m2) | 4.1 (2.6) | 4.5 (2.9) | 4.1 (2.9) | 3.9 (2.6) | 0.85 | |||
| IMAT change (kg) | −0.09 (0.3) | 0.1 (0.1) | 0.003 | −0.2 (0.2) | 0.034 | −0.1 (0.3) | 0.006 | 0.005 |
| IMATI % change | −13.0 (78.2) | 44.6 (52.6) | 0.025 | −40.0 (25.5) | 0.001 | −22.7 (86.1) | 0.133 | 0.027 |
| Initial VATI (cm2/m2) | 49.6 (34.6) | 48.5 (41.8) | 31.9 (18.0) | 54.6 (34.9) | 0.22 | |||
| VAT change (kg) | −2.1 (2.8) | 0.8 (2.0) | 0.240 | −2.0 (1.9) | 0.016 | −2.9 (2.7) | <0.001 | <0.001 |
| VATI % change | −28.5 (64.9) | 50.3 (103.0) | 0.157 | −49.6 (33.9) | 0.001 | −46.1 (33.8) | <0.001 | <0.001 |
| Initial SCATI (cm2/m2) | 71.3 (46.2) | 57.5 (28.4) | 53.0 (30.4) | 80.2 (51.8) | 0.169 | |||
| SCAT change (kg) | −2.8 (3.9) | 1.3 (1.0) | 0.003 | −2.0 (2.2) | 0.026 | −4.3 (4.0) | <0.001 | <0.001 |
| SCATI % change | −27.8 (47.9) | 36.0 (62.8) | 0.103 | −34.3 (27.4) | 0.002 | −44.8 (28.6) | <0.001 | <0.001 |
| Initial TAI (cm2/m2) | 120.9 (61.7) | 106.0 | 84.9 (41.3) | 134.8 (63.4) | 0.066 | |||
| TA change (kg) | −5.0 (5.9) | (59.1) | 0.028 | −4.1 (4.0) | 0.015 | −7.3 (5.2) | <0.001 | <0.001 |
| TAI % change | −29.5 (49.8) | 2.2 (2.6) | 0.118 | −46.2 (27.1) | <0.001 | −46.2 (27.1) | <0.001 | <0.001 |
| 37.8 (69.1) | ||||||||
| Initial SKM HU | 35.0 (7.1) | 34.3 (6.5) | 30.0 (7.3) | 36.5 (6.8) | 0.045 | |||
| SKM HU change | −0.7 (8.3) | −1.6 (5.0) | 0.34 | 9.6 (12.5) | 0.089 | −3.2 (5.3) | 0.001 | <0.001 |
| SKM HU % change | −0.04 (29.3) | −6.3 (16.2) | 0.247 | 38.1 (48.7) | 0.078 | −8.3 (15.1) | 0.003 | <0.001 |
Abbreviations: BMI, body mass index; SKMI, skeletal muscle index; IMATI, intramuscular adipose tissue index; VATI, visceral adipose tissue index; SCATI, subcutaneous adipose tissue index; TA, total adipose; TAI, total adipose index; SKM HU, skeletal muscle Hounsfield units.
Bolded values are statistically significant (P < 0.05).
a
This is the P value for in group comparison and represents whether the changes are significant within the group.