Figure 4.

Development of ovarian cancer is accompanied by muscle atrophy and progressive muscle weakness. Muscle morphology (haematoxylin and eosin staining) and quantification of the cross‐sectional area (CSA) in the tibialis anterior muscle of ES‐2 hosts. Scale bar: 100 μm (A). Whole body grip strength in animals bearing the ES‐2 tumours, reported as peak force, was measured weekly by taking advantage of a grip strength metre and expressed as the average of the three top pulls from each animal (n = 6–10) (B). Data expressed as means ± standard deviation. Significance of the differences: ^** P < 0.01, ^*** P < 0.001 vs. Control.