Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
NKT cell subsets.
| Type I or semi-invariant | Type II | ||||||
|---|---|---|---|---|---|---|---|
| TCRα chain | Vα14Jα18 (mice) | Diverse | |||||
| Vα24Jα18 (humans) | |||||||
| TCRβ chain | Vβ2, 7, 8 (mice) | Diverse | |||||
| Vβ11 (humans) | |||||||
| Representative agonists | α-GalCer, β-ManCer | Sulfatide | |||||
| Transcriptional factor | PLZF | PLZF? | |||||
| Functional subtypes | NKT1 | NKT2 | NKT17 | NKT10 | NKTFH | NKTreg | Not known |
| Transcriptional factor | T-bet | (PLZFhi) | RORγ-t | E4BP4 | Bcl-6 | Foxp3 | Not known |
| Cytokines | IFN-γ | IL-13 | IL-17 | IL-10 | IL-21 | ? | IL-4, IL-13, IFN-γ |
