Figure 5.

Ranitidine does not impact E0771-GFP tumor growth in B cell-deficient C57BL/6 mice. (A,B) E0771-GFP tumors in muMt^−/− and wild-type C57BL/6 mice treated with ranitidine (8 mg/kg) were measured every 2 days starting 7 days post E0771-GFP cell injection. (A) At day 21, the primary tumor was excised and weighed (B). Data in panel (A) represents the mean ± SEM tumor volume of 8–17 mice/point, significance was assessed using two-way ANOVA with uncorrected Fisher’s LSD multiple comparisons. Data points in panel (B) represent final tumor weight of individual mice, significance was assessed using two-way ANOVA with uncorrected Fisher’s LSD multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS, not significant.