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. 2018 Aug 15;10:28. doi: 10.3389/fnsyn.2018.00028

FIGURE 1.

FIGURE 1

Full-length human Nbea restores EPSC defects in null-mutant neurons. (A) Representative traces of continuous recordings of mEPSCs from cultured hippocampal neurons of WT, Nbea KO (KO), KO transfected with human full-length Nbea (KO + Nbea FL) and KO transfected with NbeaΔPKA (KO + NbeaΔPKA). (B) Averaged traces of mEPSCs recorded from WT (red line), KO (black), and KO + Nbea FL (dashed) neurons indicate faster kinetics in Nbea KO that can be rescued by Nbea FL. (C–F) Quantitative analysis of rise time (C), decay time (D), inter-event interval (E) and amplitude (F) of mEPSCs in WT, KO, KO + Nbea FL and KO + NbeaΔPKA. Digits in bars give the number of recorded neurons; from each neuron more than 100 consecutive mEPSCs were analyzed for evaluation. Data are means ± SEM; ∗P < 0.05, n.s., not significant; by one-way ANOVA with Tukey’s multiple comparisons test.