Table 2.
MICs of 17 antimicrobials for 9 strains.
| Antibiotics | MIC (mg/L) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| KP1276 | EC600 [pIA/C-KLUC] | EC600 | BL21 | BL21 [pET28a:: blaKLUC-5] | BL21 [pET28a:: blaKLUC-3 G240D] | BL21 [pET28a:: blaKLUC-3] | BL21 [pET28a:: blaKLUC-5 D240G] | BL21 [pET28a:: blaKLUC-5 S18G] | |
| Ampicillin | >512 | >512 | 8 | 1 | 64 | 64 | 256 | 256 | 128 |
| Meropenem | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 |
| Imipenem | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Cefotaxime | 32 | 4 | 0.12 | <0.03 | <0.03 | <0.03 | 2 | 2 | 2 |
| Cefotaxime + CLAa | 64 | 8 | 0.12 | <0.03 | <0.03 | <0.03 | 2 | 2 | 1 |
| Cefotaxime + TZBb | 2 | 0.06 | 0.06 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 |
| Ceftazidime | 8 | 1 | 0.5 | 0.06 | 0.06 | 0.06 | 0.5 | 0.5 | 0.06 |
| Ceftazidime + CLAa | 4 | 1 | 0.25 | 0.06 | 0.06 | 0.06 | 0.25 | 0.25 | 0.06 |
| Ceftazidime + TZBb | 1 | 0.5 | 0.25 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 |
| Cefepime | 32 | 4 | 0.12 | <0.03 | 0.12 | 0.12 | 0.5 | 0.5 | 0.25 |
| Cefepime + CLAa | 32 | 4 | 0.12 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 |
| Cefepime + TZBb | 4 | 0.12 | 0.12 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 |
| Piperacillin | >1024 | 128 | 4 | 1 | 16 | 16 | 32 | 32 | 16 |
| Piperacillin + TZBb | 64 | 2 | 2 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 0.25 |
| Cefazolin | >512 | 256 | 4 | 2 | 32 | 32 | 64 | 64 | 64 |
| Cefoxitin | 8 | 8 | 8 | 2 | 2 | 2 | 2 | 2 | 2 |
| Ceftriaxone | 64 | 8 | 0.125 | <0.03 | <0.03 | <0.03 | 0.25 | 0.25 | 0.25 |
aCLA, clavulanic acid at a fixed concentration of 2 mg/L; bTZB, tazobactam at a fixed concentration of 4 mg/L.