FIGURE 12.

Responses of Taar2-9^−/− male mice and wild type (WT) littermates in active place avoidance test. First 4 days in the place avoidance training apparatus represent the acquisition of the memory necessary to perform the test. From day six on the shock zone is reversed and entries into the shock zone (A), shocks per day (B) and latency to first entry into the shock zone (C) are measured. Both WT and Taar2-9^−/− mice (N = 8–9 per group) showed the same memory formation and cognitive flexibility. Thus neither hippocampus nor amygdala, which are responsible for the associative learning seem to be impaired in Taar2-9^−/− mice. Data are means ± SEM; two-way ANOVA comparing WT with Taar2-9^−/− animals.