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Probability of Detecting Effects Based on Cohort Size.
| Cohort Size (Individual Cell lines) (N) | 1 in 10 (Decile) Population Incidence (%) | 1 in 4 (Quartile) Population Incidence (%) |
|---|---|---|
| 24 | 92 | 99.9 |
| 16 | 81.5 | 99.0 |
| 4 | 34.4 | 68.3 |
The table provides exact probabilities for common population incidence frequencies and cohort sizes. Monte Carlo simulations were performed assuming a normal distribution of drug toxicity or sensitivity.
