Table 2.
Changes in serum biochemical parameters of rabbits experimentally infected with F. hepatica before and after treatment using M. oleifera seed methanolic extract
| Parameters periods (weeks) | Alanine aminotransferase (IU/l) | Aspartate aminotransferase (IU/l) | Total cholesterol (mg/dl) | Triglycerides (mg/dl) | Urea (mg/dl) | Creatinine (mg/dl) | |
|---|---|---|---|---|---|---|---|
| After infection | 0 | 28.47 ± 0.67 fg | 28.37 ± 4.78f | 39.20 ± 0.76f | 38.21 ± 3.05ef | 48.15 ± 2.08 cd | 0.95 ± 0.04a |
| 1 | 38.32 ± 1.08 cd | 40.84 ± 0.12de | 44.53 ± 3.46de | 37.86 ± 3.16ef | 45.92 ± 0.60 cd | 1.01 ± 0.00a | |
| 2 | 42.03 ± 2.25c | 46.66 ± 1.75bc | 46.68 ± 0.26 cd | 40.36 ± 0.79de | 37.77 ± 1.00f | 0.88 ± 0.00b | |
| 3 | 39.49 ± 1.81c | 48.32 ± 0.59bc | 49.60 ± 2.02c | 44.64 ± 0.11d | 40.63 ± 0.58ef | 0.55 ± 0.02d | |
| 4 | 53.99 ± 0.99a | 58.26 ± 0.47a | 40.13 ± 1.39ef | 55.00 ± 1.36c | 65.88 ± 1.76a | 0.99 ± 0.03a | |
| 5 | 52.18 ± 0.30ab | 44.65 ± 0.36 cd | 43.52 ± 0.61def | 44.18 ± 0.22d | 43.75 ± 0.26de | 0.88 ± 0.01b | |
| 6 | 53.20 ± 0.47a | 50.12 ± 0.19b | 57.72 ± 0.13b | 57.75 ± 0.11c | 63.78 ± 0.20a | 0.85 ± 0.01b | |
| 7 | 38.61 ± 0.81 cd | 39.07 ± 0.23e | 62.67 ± 1.43a | 64.64 ± 1.47b | 55.80 ± 2.32b | 0.37 ± 0.01e | |
| 8 | 42.88 ± 3.42c | 46.90 ± 0.35bc | 65.88 ± 1.78a | 65.27 ± 0.64b | 40.82 ± 0.32ef | 0.65 ± 0.03c | |
| 9 | 48.04 ± 0.45b | 51.16 ± 0.17b | 63.19 ± 0.74a | 75.07 ± 1.33a | 48.95 ± 2.79c | 0.88 ± 0.01b | |
| After treatment | 1* | 34.57 ± 0.41de | 37.13 ± 0.68e | 27.47 ± 1.69 g | 35.27 ± 6.10ef | 40.79 ± 0.40ef | 1.00 ± 0.01a |
| 2* | 27.51 ± 0.64 g | 20.62 ± 0.42 g | 44.80 ± 0.85cde | 36.89 ± 0.49ef | 44.69 ± 0.77cde | 0.85 ± 0.02b | |
| 3* | 32.25 ± 1.09ef | 27.74 ± 0.77f | 26.64 ± 0.62 g | 33.93 ± 1.64f | 45.83 ± 0.90 cd | 0.87 ± 0.01b | |
Means in the same column with different superscript letters (a, b, c…) are significant at P < 0.05
The asterisk (*) refers to the weeks of treatment