Table 1.
Intervention/signaling pathway | Molecular function/regulatory factors | Species | References |
---|---|---|---|
17-α-estradiol | Estrogen agonist | Mus musculus | 59 |
L-deprenyl | Monoamine oxidase inhibitor | Rattus norvegicus | 95 |
Acarbose | Inhibitor of intestinal α-glucosidase | M. musculus | 59 |
Aspirin | Anti-inflammatory agent | M. musculus | 163 |
Ibuprofen | Anti-inflammatory agent | Saccharomyces cerevisiae | 61 |
Caenorhabditis elegans | |||
Drosophila melanogaster | |||
Metformin | Antidiabetic drug, mTOR inhibitor, AMPK signaling pathway activator | M. musculus | 126, 140 |
C. elegans | |||
Methylene blue | Mitochondrial complex IV activator | M. musculus | 59 |
Nordihydroguaiaretic acid | Lipoxygenase inhibitor, anti-inflammatory agent | M. musculus | 59, 163 |
Rapamycin | mTOR inhibitor | M. musculus | 12, 60, 133, 134 |
D. melanogaster | |||
Resveratrol | SIRT1 activator | M. musculus | 9, 74, 188 |
C. elegans | |||
D. melanogaster | |||
S. cerevisiae | |||
Dietary restriction | mTOR, AMPK, IGF-1 | M. musculus | 71, 112, 149, 184 |
C. elegans | |||
D. melanogaster | |||
S. cerevisiae | |||
GH signaling | GH, GHR | M. musculus | 25, 39 |
Insulin/IGF-1 signaling | IGF-1, IGF-1R, PI3K, AKT, FOXO | M. musculus | 15, 65, 138 |
C. elegans | |||
D. melanogaster | |||
mTOR signaling | mTOR, S6K | M. musculus | 85, 86, 111, 156 |
C. elegans | |||
D. melanogaster | |||
S. cerevisiae |
GH, growth hormone; mTOR, mechanistic target of rapamycin.